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目的:比较原发性醛固酮增多症(PA)和原发性高血压(EH)患者腹主动脉粥样硬化(AS)斑块发生率和斑块体积,探讨PA患者AS发生发展的可能危险因素。方法:选择2012年7月1日至2015年7月1日期间因“高血压查因”住院确诊的资料完整的43例PA患者与同期确诊的年龄、性别、高血压水平及其病程等相匹配的43例EH患者为研究对象,采用64排螺旋CT检测和定量评估两组患者腹主动脉AS斑块。结果:PA患者较EH患者具有更高AS斑块发生率(62.8%vs.32.6%,P<0.05),PA患者AS斑块体积高于EH组(P<0.05)。年龄、血清低密度脂蛋白胆固醇(LDL-C)水平、醛固酮/肾素比值(ARR)与粥样斑块体积呈正相关(P<0.05)。结论 :PA患者较EH患者具有更严重的AS,年龄、LDL-C、ARR与PA患者AS的发生密切相关。
Objective: To compare the incidence and plaque volume of abdominal aortic atherosclerosis (AS) in patients with primary aldosteronism (PA) and essential hypertension (EH) and to explore the possible risk factors for the development of AS in PA patients . Methods: Forty-three PA patients with confirmed hospitalization due to “Hypertension Charlie’s Disease” during the period from July 1, 2012 to July 1, 2015 were enrolled in this study. Their age, gender, hypertension and their duration And other matched 43 cases of EH patients as the study object, using 64-slice spiral CT detection and quantitative assessment of two groups of patients with abdominal aortic AS plaque. Results: The incidence of AS plaques in patients with PA was higher than that in patients with EH (62.8% vs.32.6%, P <0.05). The plaque volume in patients with PA was higher than that in EH patients (P <0.05). Age, serum low density lipoprotein cholesterol (LDL-C) and aldosterone / renin ratio (ARR) were positively correlated with plaque volume (P <0.05). Conclusion: Patients with PA have more severe AS, age, LDL-C, and ARR than those with EH, which is closely related to the occurrence of AS in PA patients.