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目的:研究基质金属蛋白酶-9(MMP-9)基因C1562T多态性与高血压颈动脉粥样硬化的相关性。方法:原发性高血压患者120例,测定受试者双侧颈动脉内-中膜厚度(IMT),IMT≥1.3mm认为存在粥样硬化斑块。依颈动脉有无粥样硬化分为颈动脉粥样硬化组、颈动脉正常组。用聚合酶链反应-限制性片段长度多态性分析法分析2组患者的MMP-9基因C1562T的多态性。结果:颈动脉粥样硬化组与颈动脉正常组CT+TT基因型频率分别为28.8%、13.2%,差异有统计学意义(χ2=4.488,P=0.034),T等位基因与颈动脉粥样硬化发病密切相关(OR=2.092,95%CI:0.991~4.419,P=0.047)。结论:MMP-9T等位基因与高血压颈动脉粥样硬化密切相关,可能是其遗传标志。
Objective: To investigate the relationship between the C1562T polymorphism of matrix metalloproteinase-9 (MMP-9) and carotid atherosclerosis in hypertension. Methods: One hundred and twenty patients with essential hypertension were enrolled in this study. The bilateral carotid intima - media thickness (IMT) and IMT ≥1.3 mm were considered as atherosclerotic plaques. According to whether carotid artery atherosclerosis is divided into carotid atherosclerosis group, carotid artery normal group. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to analyze the polymorphism of MMP-9 gene C1562T in two groups. Results: The frequencies of CT + TT genotype in carotid atherosclerosis group and normal carotid artery group were 28.8% and 13.2%, respectively (χ2 = 4.488, P = 0.034). The frequencies of T allele and carotid atherosclerosis The incidence of SS was closely related (OR = 2.092, 95% CI: 0.991 ~ 4.419, P = 0.047). Conclusion: The MMP-9T allele is closely related to carotid atherosclerosis in hypertension and may be the genetic marker.