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目的:观察固本通关饮治疗糖尿病肾病的临床疗效,及对一氧化氮(NO)/血清内皮素(ET)、血清基质金属蛋白酶(MMP)/基质金属蛋白酶抑制剂(TIMP)失衡的影响。方法:将100例符合标准的糖尿病肾病患者随机分为治疗组和对照组各50例,对照组采用西医常规治疗,治疗组在对照组治疗基础上加服固本通关饮。观察临床疗效,及治疗前后中医证候积分、生存质量评分及血清ET-1、NO、MMP-9、TIMP-1水平的变化。结果:总有效率治疗组为88%,对照组为74%,2组比较,差异有显著性意义(P<0.05)。2组治疗后中医证候积分及生存质量评分比较,差异均有显著性意义(P<0.05)。治疗前后组内比较,差异均有非常显著性意义(P<0.01)。2组血清ET-1、NO、MMP-9、TIMP-1水平治疗后比较,差异有显著性或非常显著性意义(P<0.01,P<0.05)。2组治疗前后组内比较,差异均有非常显著性意义(P<0.01)。结论:固本通关饮能够较好地改善患者的临床症状和生化指标,提高患者的生存质量。
Objective: To observe the clinical efficacy of Guben Tongguan Decoction in the treatment of diabetic nephropathy and the effects of nitric oxide (NO) / serum endothelin (ET), serum matrix metalloproteinase (MMP) / matrix metalloproteinase inhibitor (TIMP) imbalance. Methods: 100 cases of diabetic nephropathy patients were randomly divided into treatment group and control group, 50 cases in each group. The control group was treated with conventional western medicine. The treatment group received Gubeng Tongguan Drink on the basis of the control group. The clinical curative effect, TCM syndrome score, quality of life score, serum ET-1, NO, MMP-9 and TIMP-1 levels before and after treatment were observed. Results: The total effective rate was 88% in the treatment group and 74% in the control group. There was significant difference between the two groups (P <0.05). After treatment, TCM syndrome scores and quality of life scores were significantly different (all P <0.05). Before and after treatment, the differences were significant (P <0.01). The levels of serum ET-1, NO, MMP-9 and TIMP-1 in the two groups were significantly different between the two groups after treatment (P <0.01, P <0.05). There were significant differences between the two groups before and after treatment (P <0.01). Conclusion: Guben Tongguan drink can better improve the clinical symptoms and biochemical indicators of patients and improve the quality of life of patients.