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目的观察多潘立酮联合复方消化酶治疗功能性消化不良(FD)患者的临床效果。方法选取该院2014年5月-2016年4月收治的FD患者78例,在患者知情同意下给予双盲分组,分为观察组与对照组各39例。2组均给予多潘立酮治疗,在此基础上,观察组加服复方消化酶治疗,比较2组治疗前后症状改善情况、疗效及不良反应发生情况。结果 2组治疗后消化系统症状评分均较治疗前明显下降,且观察组低于对照组;观察组总有效率为92.31%显著高于对照组的69.23%,差异均有统计学意义(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论 FD患者治疗中多潘立酮、复方消化酶联合用药,较多潘立酮单独用药治疗有效性增加,安全性高,具有较高的临床价值。
Objective To observe the clinical effect of domperidone combined with compound digestive enzyme in patients with functional dyspepsia (FD). Methods Seventy-eight FD patients admitted to our hospital from May 2014 to April 2016 were enrolled in this study. Patients were divided into observation group and control group with 39 patients with informed consent. Two groups were given domperidone treatment, on this basis, the observation group plus compound digestive enzyme treatment, compared two groups before and after treatment to improve the symptoms, efficacy and adverse reactions. Results The score of digestive system symptom in both groups after treatment was significantly lower than that before treatment, and the observation group was lower than the control group. The total effective rate was 92.31% in the observation group, which was significantly higher than that in the control group (69.23%, P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion FD patients treated with domperidone, compound digestive enzymes combined with more domperidone alone increased the effectiveness of treatment, high safety, with high clinical value.