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目的 观察米非司酮用于治疗更年期功能性子宫出血的疗效。方法 选择 6 0例已确诊的更年期功能性子宫出血患者随机分为米非司酮和性激素治疗组。米非司酮组 30例诊刮后第 1天每日口服米非司酮 2 5mg ,连服 3个月。对照组于诊刮后第 1天每日口服避孕药 1号共服 2 0d ,下次月经来潮后第 5天进行第2周期 ,共 3个月。结果 米非司酮组复发率及闭经率与对照组比较 ,差异有显著意义 (P <0 0 1)。结论 小剂量米非司酮治疗更年期功能性子宫出血安全有效 ,且无明显不良反应。
Objective To observe the efficacy of mifepristone in the treatment of menopausal functional uterine bleeding. Methods Sixty patients with diagnosed menopause functional uterine bleeding were randomly divided into mifepristone and sex hormone treatment groups. Mifepristone group of 30 cases of the first day after oral administration of mifepristone 25mg, even for 3 months. The control group on the first day after diagnosis of oral contraceptives daily co-service 20d, the next menstrual cramps on the 5th day of the second cycle, a total of 3 months. Results The recurrence rate and amenorrhea rate in the mifepristone group were significantly different from those in the control group (P <0.01). Conclusion Low dose mifepristone is safe and effective in the treatment of climacteric functional uterine bleeding without obvious adverse reaction.