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目的研究血管紧张素转化酶（ＡＣＥ）基因的插入／缺失（Ｉ／Ｄ）多态性与原发性高血压的关系。方法应用ＰＣＲ的方法分别检测７２例原发性高血压患者和９３例正常血压组的ＡＣＥ基因第１６内含子的Ｉ／Ｄ多态性。结果共得到３种基因型：纯合缺失型（ＤＤ），纯合插入型（Ｉ），杂合型（ＩＤ）。原发性高血压患者Ｄ等位基因的频率（０．６２）高于健康对照组（０．４８）（Ｐ＜０．０５）。结论ＡＣＥ基因的Ｉ／Ｄ多态性可能与原发性高血压有关。
Objective To investigate the relationship between the insertion / deletion (I / D) polymorphism of angiotensin-converting enzyme (ACE) gene and essential hypertension. Methods PCR-based method was used to detect the I / D polymorphism of intron 16 intron in 72 patients with essential hypertension and 93 patients with normal blood pressure. Results A total of three genotypes were obtained: homozygous deletion (DD), homozygous insertion (I) and heterozygous (ID). The frequency of D allele in patients with essential hypertension (0.62) was higher than that in healthy controls (0.48) (P <0.05). Conclusion The ACE gene I / D polymorphism may be related to essential hypertension.