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目的探讨小剂量米索前列醇和缩宫素在足月引产中的效果和安全性。方法前瞻性选择本院2012年1月-2013年1月病房收治的,符合引产指证的单胎足月妊娠孕产妇120例,按随机数字法分为2组,A组60例孕产妇引产前给予米索前列醇25μg置于阴道后穹窿处,B组60例患者静脉滴注给予缩宫素2.5U。结果 A组产妇在给药后8h Bishop评分、临产时间、诱发宫缩时间和总产程时间方面均显著好于B组(P<0.05),A组总有效率达83.3%,显著高于B组56.7%(P<0.05),两组顺产率分别为93.3%和65.0%(P<0.05),两组在产后出血量、新生儿窒息和新生儿Apgar评分方面差异不显著(P>0.05),且均未见严重不良反应。结论两种药物各具特色,其中米索前列醇效果更显著,能显著缩短临床时间和产程,提高顺产率,值得推广。
Objective To investigate the efficacy and safety of low-dose misoprostol and oxytocin in term induction of labor. Methods 120 cases of singletonic full-term pregnant women who were admitted to our ward from January 2012 to January 2013 in our hospital were randomly divided into two groups according to random number method. A group of 60 pregnant women before labor induction 25 μg of misoprostol was administered to the vaginal fornix, and 60 patients in group B received oxytocin 2.5 U intravenously. Results The Bishop score, labor time, induced uterine contractions and total labor duration in group A were significantly better than those in group B at 8h (P <0.05). The total effective rate in group A was 83.3%, which was significantly higher than that in group B 56.7% (P <0.05). The birth rate of the two groups was 93.3% and 65.0% respectively (P <0.05). There was no significant difference between the two groups in postpartum hemorrhage, neonatal asphyxia and neonatal Apgar score (P> 0.05) And no serious adverse reactions. Conclusion The two drugs have their own characteristics, including misoprostol effect is more significant, can significantly shorten the clinical time and labor process, improve the yield, it is worth promoting.