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目的 探讨糖一脂双能源部分肠外营养 (PPN)配合肝动脉栓塞化疗 (TACE)对肝癌患者肝功能、营养状态及肿瘤生长的影响。方法 5 8例肝癌患者随机分为含脂组 (30例 )与对照组 (2 8例 ) ;两组行 TACE每月 1次 ,连续 3次 ,同时 ,按组别每月给予含或不含脂肪乳剂 PPN 1周、连续 3个月 ;治疗前及治疗后每月测 AL T、AST、TB、血清蛋白、AFR与 AFU,治疗后每月计算肿瘤生长率。结果 与对照组比较 ,治疗后含脂组 AL T、AST及 TB有不同程度下降 ,血清蛋白有不同程度升高 ;两组治疗后 AFP与 AFU变化幅度及每月肿瘤生长率相近。结论 糖一脂双能源 PPN可改善肝癌患者肝功能及营养状态 ;配合 TACE治疗 ,对肿瘤生长并无明显促进作用
Objective To investigate the effect of partial parenteral nutrition (PPN) combined with hepatic artery embolization chemotherapy (TACE) on hepatic function, nutritional status and tumor growth in patients with hepatocellular carcinoma. Methods 58 patients with liver cancer were randomly divided into a lipid-containing group (30 cases) and a control group (28 cases); both groups performed TACE once a month for 3 consecutive times, and at the same time, each group was given monthly or not. Intralipid PPN was for 1 week and 3 consecutive months; AL T, AST, TB, serum protein, AFR, and AFU were measured monthly before and after treatment, and the tumor growth rate was calculated monthly after treatment. Results Compared with the control group, AL T, AST, and TB in the lipid-containing group decreased to varying degrees after treatment, and serum protein levels increased in different degrees. After treatment, the change extent of AFP and AFU and the monthly tumor growth rate were similar. Conclusion PPN can improve the liver function and nutritional status of liver cancer patients; TACE treatment does not significantly promote tumor growth.