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目的评价14肽生长抑素(施他宁)和大黄联用治疗重症急性胰腺炎(acute severity pancreatitis,SAP)的疗效。方法采用施他宁和大黄联用治疗42例SAP患者,并与未用大黄治疗的40例患者作比较,观察两组治疗期间第1天、第3天、第5天APACHEⅡ评分,以及血清淀粉酶、血肌酐(Cr)、血钙、血糖、白细胞计数的变化、腹痛、腹胀等主要临床症状改善情况及禁食和住院天数、并发症发生率、手术率和死亡率。结果与对照组相比,施他宁和大黄联用治疗重症急性胰腺炎,能减少并发症,降低手术率及死亡率,缩短禁食、腹痛、腹胀的时间及住院天数。结论施他宁和大黄联合治疗SAP具有良好的效果。
Objective To evaluate the efficacy of 14-peptide somatostatin (Sitatlon) combined with rhubarb for the treatment of acute severe pancreatitis (SAP). Methods Forty-two patients with SAP were treated with combination of situtin and rhubarb, and compared with 40 patients without rhubarb. The APACHEⅡscores on day 1, day 3 and day 5 of the two groups were observed, Enzyme, serum creatinine (Cr), blood calcium, blood glucose, white blood cell count changes, abdominal pain, abdominal distension and other major clinical symptoms and fasting and hospitalization days, complications, surgery and mortality. Results Compared with the control group, the combination of Sitadin and rhubarb for the treatment of severe acute pancreatitis can reduce complications, reduce the operation rate and mortality, shorten the fasting, abdominal pain, bloating time and hospital stay. Conclusion Strychnine and rhubarb combined treatment of SAP has a good effect.