,Applications of nanostructures in wide-field, label-free super resolution microscopy

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Super resolution imaging capable of resolving details beyond the diffraction limit is highly desired in many scientific and application fields,including bio-medicine,nanomaterial science,and opto-electronic integration.Up to now,many different methods have been proposed,among which wide-field,label-free super resolution microscopy is indispensable due to its good applicability to diverse sample types,large field of view (FOV),and high imaging speed.In recent years,nanostructures have made a crucial contribution to the wide-field,label-free subdiffraction microscopy,with various working mechanisms and configuration designs.This review summarizes the recent applications of the nanostructures in the wide-field,label-free super resolution microscopy,with the emphasis on the designs of hyperlens with hyperbolic dispersion,microsphere with "nano-jets",and nanowire ring illumination microscopy based on spatial frequency shift effect.The bottlenecks of the current techniques and possible solutions are also discussed.
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