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[目的]探讨血浆置换(PE)与连续血液净化(CBP)治疗肝功能衰竭(HF)患者的临床疗效.[方法]本院HF患者84例,依据治疗方案不同分为两组,观察组42例,实施PE+CBP干预;对照组42例,采用内科综合干预联合PE治疗,比较两组疗效和血生化指标、肝功能、细胞因子指标变化及不良反应发生情况.[结果]观察组治疗有效率为83 .33%(35／42) ,显著高于对照组的69 .05%(29／42) ,且差异有显著性( P ＜0 .05) .治疗后两组白蛋白(ALB)、总胆汁酸(TBA)、胆碱酯酶(CHE)、总胆红素(TBIL)、谷丙转氨酶(ALT ) ,谷草转氨酶(AST )、凝血酶原活动度(PT A)水平较治疗前显著改善( P ＜0 .05) ;观察组各项指标改善幅度明显优于对照组( P ＜0 .05) ;观察组肿瘤坏死因子a(T NF‐α) 、白介素6(IL‐6)水平较对照组显著降低,且两组比较差异有显著性( P ＜0 .05) .观察组不良反应发生率显著低于对照组( P ＜0 .05) .[结论]PE联合CBP可有效改善肝衰竭患者肝功能,缓解症状,清除炎性因子,减少不良反应.“,”To analyze the clinical effect of plasma exchange (PE) combined with continuous blood purification(CBP) in the treatment of patients with liver failure (HF).[M ethods]A total of 84 HF patients were divided into two groups ;the observation group ( n ＝42 cases ,the implementation of PE+CBP) and the control group ( n ＝42 cases ,comprehensive intervention of PE treatment ).Clinical curative effect ,blood biochemical in‐dexes ,liver function ,cytokines ,and adverse reactions were compared between the two groups .[Results]T he ef‐fective rate of the observation group was 83 .33%(35／42) ,which was significantly higher than that of the control group 69 .05%(29／42) ,and the difference was significant ( P ＜0 .05).TBIL ,AL T ,AST ,PT A ,ALB ,TBA and CHE in the two groups were significantly improved after treatment ( P ＜0 .05).T he improvement in the observa‐tion group was significantly better than that in the control group ( P ＜0 .05).T he levels of T NF‐alpha and cyto‐kine IL‐6 in the observation group were significantly lower than those in the control group ,and the difference be‐tween the two groups was significant ( P ＜0 .05).T he effective rate of observation group was significantly higher than that of control group ( P ＜0 .05).T he adverse reaction rate in the observation group was significantly lower than that in the control group ( P ＜0 .05).[Conclusion]PE combined with CBP can effectively improve liver func‐tion ,relieve symptoms ,remove inflammatory factors ,and reduce complications in patients with liver failure .