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目的讨论佛山市汉族女性MTHFR(5,10-亚甲基四氢叶酸还原酶)、MTRR(甲硫氨酸合成酶还原酶)基因频率多态性特征,用以指导孕期妇女增补叶酸和出生缺陷一级预防。方法选取2014年7月-2015年4月在该院进行孕栓的584例汉族妇女的样本,检测MTHFR C677T、A1298C和MTRR A66G基因分型及统计分析其出现频率,并与其他16个地区汉族女性数据进行比较。结果佛山市汉族女性MTHFR 677 TT基因型频率,仅与南宁(7.7%)、琼海(6.1%)相比差异没有统计学意义(P>0.05),T等位基因频率仅与南宁(24.1%)、琼海(22.1%)相比差异没有统计学意义;MTHFR 1298 AC基因型频率仅与南宁(37.9%)、琼海(35.6%)相比差异没有统计学意义,C等位基因频率与其他城市相比均有统计学意义(P<0.05);MTRR 66 AG基因型频率仅与尚志(40.4%)、乌鲁木齐(38.7%)、惠州(39.8%)、琼海(43.2%)相比差异没有统计学意义,G等位基因频率仅与乌鲁木齐(26.1%)、琼海(30.9%)相比差异没有统计学意义。结论佛山市汉族女性MTHFR和MTRR基因频率多态性不同于其他地区,具有地域特异性。
Objective To discuss the frequency polymorphisms of MTHFR (5,10-methylenetetrahydrofolate reductase) and MTRR (methionine synthase reductase) gene in Foshan Han women to guide the women during pregnancy to supplement folic acid and birth defects Primary prevention. Methods A total of 584 Han women who were pregnant in our hospital from July 2014 to April 2015 were enrolled in this study. Genotypes of MTHFR C677T, A1298C and MTRR A66G were detected and statistically analyzed. The frequency of occurrence was also compared with that of other Han Chinese Female data are compared. Results The frequencies of MTHFR 677 TT genotypes in Foshan Han women were not significantly different from those in Nanning (7.7%) and Qionghai (6.1%) (P> 0.05) ) And Qionghai (22.1%). The frequency of MTHFR 1298 AC genotype was not significantly different from that of Nanning (37.9%) and Qionghai (35.6%). The frequencies of C allele and (P <0.05). The genotype frequency of MTRR 66 AG was only lower than that of Shangzhi (40.4%), Urumqi (38.7%), Huizhou (39.8%) and Qionghai (43.2%) No statistical significance, G allele frequency only with Urumqi (26.1%), Qionghai (30.9%) compared with no significant difference. Conclusion The frequencies of MTHFR and MTRR genes in Foshan Han women are different from those in other regions and are regionally specific.