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氧衍生游离基如过氧化物、过氧化氢和羟基均为高度反应性毒物。正常氧代谢时产生少量该类毒性物质,由内源性细胞内酶解毒。这些细胞内酶统称游离基清除剂(FRS),包括超氧物歧化酶(SOD)和过氧化氢酶(CAT)。本研究旨在估价氧衍生游离基在犬实验性胰腺炎发病机理中的作用和FRS对实验性胰腺炎的保护作用。材料与方法:用健康杂种狗(18～22 kg)作离体胰腺实验。在巴比妥钠(30mg/kg)麻醉下分离胰腺,保留与其相连的部分十二指肠段。自脾动脉、肠系膜上动
Oxygen derived radicals such as peroxides, hydrogen peroxide and hydroxyl are highly reactive poisons. A small amount of this type of toxic substances produced by normal oxygen metabolism, enzymatic detoxification by endogenous cells. These intracellular enzymes are collectively referred to as free radical scavengers (FRSs) and include superoxide dismutase (SOD) and catalase (CAT). The purpose of this study was to evaluate the role of oxygen-derived free radicals in the pathogenesis of experimental pancreatitis in dogs and the protective effect of FRS on experimental pancreatitis. MATERIALS AND METHODS: Ex vivo pancreatic experiments were conducted with healthy mongrel dogs (18-22 kg). The pancreas was isolated under anesthesia with sodium pentobarbital (30 mg / kg), retaining the portion of the duodenum connected to it. Since the spleen artery, the mesenteric move