目的　通过对２０ 例恶性淋巴系统肿瘤患儿的治疗，探索左旋门冬酰胺酶（ＬＡＳＰ） 安全、有效的用药方式，指导临床治疗。方法　将２０ 例患儿随机分为每天用药组及隔天用药组，两组均用８次ＬＡＳＰ，每次６０００ ＫＵ／ｍ２（１ ＫＵ＝１ＩＵ） 静脉滴注，每次用药前检测血清中ＬＡＳＰ活性及其底物门冬酰胺水平，以比较两种用药方法的差异性，并观察其不良反应之差异。结果　每天用药组血清中ＬＡＳＰ谷值水平明显高于隔天用药组（Ｐ＜０ ．０１） ；两组门冬酰胺最低浓度的平均水平及分布情况差距不大（ Ｐ＞０ ．０５） ；每天用药组消化道反应、血清清蛋白水平下降及ＡＬＴ（ＧＰＴ） 升高的发生率明显高于隔天组（ Ｐ＜０ ．０５）。结论　隔天每次ＬＡＳＰ６０００ ＫＵ／ｍ２ 静脉滴注为安全、有效的用药方法 Objective To investigate the treatment of 20 malignant lymphatic system tumors in children and explore the safe and effective way of using L-asparaginase (LASP) to guide clinical treatment. Methods Twenty patients were randomly divided into daily medication group and the other day medication group. Each group was treated with 8 times of L-ASP every 6000 KU / m2 (1 KU = 1 IU) intravenous drip. Serum L -ASP activity and its substrate asparagine levels in order to compare the differences between the two methods of treatment, and observe the differences in adverse reactions. Results The serum levels of LASP in the daily medication group were significantly higher than those in the other day medication group (P <0.01). There was no significant difference in the average level and distribution of the minimum asparagine concentrations between the two groups (P> 0.05) The incidence of digestive tract reaction, serum albumin level and the increase of ALT (GPT) in the daily medication group were significantly higher than those in the other day group (P <0.05). Conclusion The next day each L  ASP 6000 KU / m2 intravenous infusion for safe and effective drug treatment