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目的探讨妊娠合并梅毒患者发生不良妊娠结局相关影响因素。方法收集2007年7月-2010年12月深圳市南山区内所建立的梅毒孕妇及其所分娩的新生儿的专项病历资料,对其中28例发生不良妊娠结局和199例正常妊娠结局患者进行巢式病例对照研究,对梅毒孕妇人口学特征和临床特征相关变量进行单因素和多因素分析。结果单因素分析显示梅毒孕妇的婚姻状况、就诊时TRUST滴度和是否有配偶以外的其他性伴与发生不良妊娠结局有关,多因素分析结果进一步证实梅毒孕妇婚姻状况(OR=4.111,P=0.019)和就诊时TRUST滴度(OR=3.233,P=0.015)与孕妇的妊娠结局相关。结论梅毒孕妇的未婚和离异的婚姻状况、就诊时TRUST滴度大于1:8是发生不良妊娠结局的危险因素。
Objective To investigate the influencing factors of adverse pregnancy outcomes in patients with syphilis during pregnancy. Methods The data of special medical records of syphilis and its newborn infants born in Nanshan District of Shenzhen City from July 2007 to December 2010 were collected and 28 cases of adverse pregnancy outcomes and 199 cases of normal pregnancy outcomes were collected. Type case-control study on univariate and multivariate analysis of demographic and clinical variables related to syphilis. Results Univariate analysis showed that the marital status of syphilis pregnant women, the TRUST titers at the time of treatment and the presence or absence of partners other than spouses were associated with adverse pregnancy outcomes. Multivariate analysis further confirmed the marital status of syphilis pregnant women (OR = 4.111, P = 0.019 ) And TRUST titers (OR = 3.233, P = 0.015) at the time of visit were associated with pregnancy outcomes in pregnant women. Conclusion The marital status of unmarried and divorced syphilis pregnant women, TRUST titers greater than 1: 8 at treatment is a risk factor for adverse pregnancy outcomes.