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目的 :制备美沙拉嗪缓释片剂 ,并评价其体外释放特性。方法 :用正交试验设计对片剂的处方进行筛选 ,制备美沙拉嗪缓释片剂 ,测定其释放特性。结果 :以优选的处方所制备的片剂 ,体外释药性能符合Higuchi模型 ,持续释药达 8h。结论 :该片剂工艺简单 ,可适合工业化生产
Objective: To prepare mesalazine sustained-release tablets and to evaluate its in vitro release characteristics. Methods: Orthogonal design was used to screen the prescriptions of tablets. Mesalazine sustained-release tablets were prepared and their release characteristics were determined. Results: The tablets prepared with the preferred prescription showed good in vitro drug release performance in accordance with Higuchi’s model and sustained release for 8 hours. Conclusion: The tablet process is simple, suitable for industrial production