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目的研究胺碘酮静脉注射联合口服用药治疗恶性心律失常的临床效果。方法 64例恶性心律失常患者,随机分为实验组和对照组,每组32例。实验组患者应用胺碘酮静脉注射联合口服用药治疗,对照组患者应用胺碘酮静脉注射治疗,对比两组患者的治疗效果。结果两组患者临床治疗显效率比较差异无统计学意义(P>0.05);实验组并发症发生率(3.1%)低于对照组(21.9%),差异具有统计学意义(P<0.05)。经过1年随访,实验组无一例复发,复发率为0;对照组有5例复发,复发率为15.6%;实验组复发率低于对照组,差异具有统计学意义(P<0.05)。结论胺碘酮不同给药方法治疗恶性心律失常,其临床疗效无明显差异,但静脉注射联合口服用药能够减少并发症的发生,降低复发率。
Objective To study the clinical effect of intravenous amiodarone combined with oral medication in the treatment of malignant arrhythmia. Methods 64 patients with malignant arrhythmia were randomly divided into experimental group and control group, 32 cases in each group. Patients in the experimental group were treated with intravenous injection of amiodarone combined with oral medication, and patients in the control group were treated with intravenous injection of amiodarone. The therapeutic effect was compared between the two groups. Results There was no significant difference in clinical curative effect between the two groups (P> 0.05). The incidence of complications in the experimental group (3.1%) was lower than that in the control group (21.9%). The difference was statistically significant (P <0.05). After one year of follow-up, there was no recurrence in the experimental group, with a recurrence rate of 0; in the control group, 5 cases were relapsed with a recurrence rate of 15.6%. The recurrence rate of the experimental group was lower than that of the control group (P <0.05). Conclusions Amiodarone administration of different methods of treatment of malignant arrhythmia, no significant difference in clinical efficacy, but the combination of intravenous injection and oral administration can reduce the incidence of complications and reduce the recurrence rate.