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对24例非典型增生和173例胃癌活检组织中P~(53)蛋白的免疫组化结果分析表明:51.1％的高分化管状腺癌,58.4％的髓样癌、硬癌,59％的印戒、粘液癌病变组织中均有不同程度的P~(53)蛋白异常表达。11％的轻度非典型增生,20％的中、重度非典型增生也存在不同程度的P~(53)蛋白异常表达。结果提示:在胃癌的发生发展过程中,P~(53)蛋白的异常表达和P~(53)蛋白产物聚积呈明显的递增现象,是癌变过程的早期生物分子改变。这种时相改变可能对胃癌的早期诊断,恶性程度的判断,估价预后有一定作用。
Immunohistochemical analysis of P53 protein in 24 cases of atypical hyperplasia and 173 cases of gastric cancer biopsy showed that: 51.1% of highly differentiated tubular adenocarcinoma, 58.4% of medullary carcinoma, hard cancer, 59% of India Abnormal expression of P53 protein was observed in various tissues of abstinence and mucinous carcinoma. 11% of mild atypical hyperplasia, 20% of moderate-to-severe atypical hyperplasia also have different degrees of abnormal expression of P53 protein. The results suggest that during the development of gastric cancer, the abnormal expression of P53 protein and the accumulation of P53 protein product are evidently increasing, which is an early biomolecular change in the process of carcinogenesis. This phase change may have an effect on the early diagnosis of gastric cancer, the judgment of malignancy, and the evaluation of prognosis.