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[目的]探讨联合检测血清甲胎蛋白(AFP)及甲胎蛋白异质体(AFP-L3)含量在肝癌诊断中的意义。[方法]采用全自动化学发光分析技术检测185例肝癌患者、225例肝良性病变患者以及200名健康对照中血清AFP和AFP-L3的含量。[结果]肝癌组、肝脏良性病变组AFP、AFP-L3值均高于正常对照组(P<0.05),肝癌组AFP和AFP-L3水平均高于肝脏良性病变组(P<0.05)。AFP诊断肝癌的灵敏度为68.11%,特异性为80.94%;而AFP-L3灵敏度为83.78%,特异性为96.00%;AFP及AFP-L3联合检测的灵敏度为93.51%,特异性为78.35%。[结论]AFP、AFP-L3联合检测对肝癌早期诊断及鉴别诊断具有一定意义。
[Objective] To explore the significance of combined detection of serum alpha-fetoprotein (AFP) and alpha-fetoprotein (AFP-L3) in the diagnosis of liver cancer. [Methods] The contents of serum AFP and AFP-L3 in 185 patients with hepatocellular carcinoma, 225 patients with benign liver disease and 200 healthy controls were detected by automatic chemiluminescence analysis. [Results] The levels of AFP and AFP-L3 in liver cancer group and benign liver disease group were significantly higher than those in normal control group (P <0.05). The levels of AFP and AFP-L3 in liver cancer group were significantly higher than those in benign liver disease group (P <0.05). The sensitivity and specificity of AFP-HFP were 68.11% and 80.94%, respectively. The AFP-L3 sensitivity and specificity were 83.78% and 96.00%, respectively. The sensitivity and specificity of AFP and AFP-L3 were 93.51% and 78.35% respectively. [Conclusion] The combined detection of AFP and AFP-L3 has some significance for the early diagnosis and differential diagnosis of liver cancer.