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目的探讨肝血管平滑肌脂肪瘤(HAML)临床病理特征免疫组化表达及其意义。方法结合文献资料,回顾性分析4例HAML的临床病理形态及其免疫组化表达情况。结果 1、HAML的临床症状和实验检查无特征性,影像学显示肝内占位病灶;2、免疫组化示HMB45、SMA、Malen-A高表达,Vimentin、S-100阳性表达,AFP、CK,EMA、P53、Ki67阴性表达。结论综合分析HAMA形态变化及免疫组化检测有助于确定,HMB45、SMA是有意义的诊断、鉴别诊断指标。
Objective To investigate the clinical and pathological features of hepatic angiomyolipoma (HAML) by immunohistochemistry and its significance. Methods According to the literature, the clinicopathological features and immunohistochemical expression of HAML in 4 cases were retrospectively analyzed. The results of immunohistochemistry showed that HMB45, SMA and Malen-A were highly expressed, the expression of Vimentin and S-100 was positive, AFP and CK were positive , EMA, P53, Ki67 negative expression. Conclusion Comprehensive analysis of HAMA morphological changes and immunohistochemical detection is helpful to determine, HMB45, SMA is a meaningful diagnostic and differential diagnosis.