论文部分内容阅读
目的探讨凝血指标在慢性阻塞性肺疾病(COPD)中的临床意义。方法选取2014年4月至2015年6月在沈阳市第十医院就诊的COPD患者137例为研究对象,按照病情轻重不同分为COPD急性期组(AECOPD组)70例和COPD稳定期组67例,另外选取健康体检者100例作为对照组。分别检测3组受检者的血浆凝血酶原时间(PT)、血浆纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)、血浆凝血酶时间(TT)及D-二聚体(DD)。结果 AECOPD组患者PT、APTT、TT指标明显低于对照组及COPD稳定期组,FIB、DD明显高于对照组及COPD稳定期组,差异均有统计学意义(均P<0.05);COPD稳定期组PT、APTT、TT均明显低于对照组,差异有统计学意义(P<0.05);COPD稳定期组FIB、DD明显高于对照组,差异均有统计学意义(均P<0.05)。结论 AECOPD患者与COPD稳定期患者的PT、APTT、TT明显低于健康人群,FIB、DD明显高于健康人群,检测COPD患者的凝血功能,可以预防肺血栓形成。
Objective To investigate the clinical significance of coagulation index in chronic obstructive pulmonary disease (COPD). Methods A total of 137 COPD patients treated in the 10th Hospital of Shenyang from April 2014 to June 2015 were selected as study subjects and divided into 70 COPD acute stage patients (AECOPD group) and 67 COPD stable patients , Another 100 healthy subjects were selected as the control group. The prothrombin time (PT), fibrinogen (FIB), activated partial thromboplastin time (APTT), plasma thrombin time (TT) and D-dimer ). Results The indexes of PT, APTT and TT in AECOPD group were significantly lower than those in control group and stable COPD group (P <0.05). The FIB and DD levels in AECOPD group were significantly higher than those in control group and stable COPD group (all P <0.05) The levels of PT, APTT and TT in the period group were significantly lower than those in the control group (P <0.05). The FIB and DD levels in the stable COPD group were significantly higher than those in the control group (all P <0.05) . Conclusions The PT, APTT, TT of AECOPD patients and stable COPD patients were significantly lower than those of healthy people, and FIB and DD were significantly higher than those of healthy people. Detecting the coagulation function of patients with COPD could prevent pulmonary thrombosis.