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目的研究小鼠静脉注射(iv)和灌胃(ig)偏二甲基肼(UDMH)的毒物动力学,及ivUDMH的组织分布。方法iv组,剂量39·0mg/kg;ig组,剂量39·0mg/kg和78·0mg/kg;iv组织分布组,剂量78·0mg/kg。染毒后不同时间断头取血及剖取相关脏器组织,并测定样品中UDMH浓度。结果小鼠ivUDMH呈二室开放模型,分布相半衰期(t1/2α)仅为2·98min,清除相半衰期(t1/2β)为30·0~39·6min。小鼠igUDMH为一级吸收一室模型,吸收相半衰期(t1/2ka)仅3·6~4·5min,吸收达峰时间(tp)不足15min,吸收分数(F)为100%。小鼠ivUDMH,脏器中UDMH浓度,除脑外均呈单项指数函数下降,在脑中还有一个上升相。各脏器组织的靶向系数(te)均大于1,消化道的重量加权靶向系数(te*)高达7·1。结论UDMH经小鼠消化道吸收快且完全,分布很快且广泛;血脑屏障对UDMH进入脑有一定的阻碍作用;消除快,物质蓄积性弱。
Objective To study the toxicokinetics of iv dimethoate (UDMH) and ivUDMH tissue in mice. Methods iv group, dose 39 · 0mg / kg; ig group, the dose of 39 · 0mg / kg and 78 · 0mg / kg; iv tissue distribution group, a dose of 78 · 0mg / kg. At different times after exposure to decapitation and dissection related organ tissue samples, and determination of UDMH concentration in the sample. Results The mouse ivUDMH showed a two-compartment open model with a half-life (t1 / 2α) of only 2.98 min and a clear phase half-life (t1 / 2β) of 30.0 to 39.6 min. The mouse igUDMH was a one-compartment one-compartment model with an absorption half-life (t1 / 2ka) of only 3.6-6.5 min, an uptake peak time (tp) of less than 15 min and an absorption fraction (F) of 100%. Mice ivUDMH, UDMH concentrations in organs, except for a single exponential function decreased in the brain, there is a rising phase in the brain. Targeting coefficients (te) for each organ were greater than 1, and the weight-for-weight targeting factor (te *) for the digestive tract was as high as 7.1. Conclusion UDMH absorbed rapidly and completely, rapidly and extensively by the digestive tract of mice. The blood-brain barrier has a certain impeding effect on the brain of UDMH;