A novel β-PbO2 anode modified with fluorine resin was developed for typical pollutant electrocatalytic degradation and wastewater treatment. Various operating parameters such as applied voltage (3.5-10.5 V), pH (2-6), salinity of the electrolyte (0.5-2 g／L K2SO4) and initial phenol concentration (100-400 mg／L) were investigated to explore the electrocatalytic ability of the anode by taking phenol as sample. A preliminary study on dyeing wastewater treatment by this method indicated that the biodegradability could be increased to suit subsequent biological treatment. The stability of the anode has been proved to be high against acidity. The anode showed promising application for treatment of wastewater, especially of high salinity and high acidity wastewater.