Hb Leiden 是由于血红蛋白β链 N 端第六或第七位的谷氨酸缺失所致,是一种罕见的异常血红蛋白分子病。1968年 De jong等首次在荷兰的 Leiden 发现,迄今世界共报导三例。1978年在江西萍乡首次发现我国 Hb Leiden-β(或β~+)地中海贫血症和G6PD 缺乏。1980年我们在血红蛋白分子 Hb Leiden is a rare abnormal hemoglobin molecule disease caused by the absence of glutamic acid at the sixth or seventh N-terminal of the hemoglobin β chain. In 1968, De jong et al first discovered in Leiden, the Netherlands, so far, three cases were reported in the world. In 1978, Pingxiang, Jiangxi Province for the first time found that our country Hb Leiden-β (or β ~ +) thalassemia and G6PD deficiency. In 1980 we are on hemoglobin