Functional spermatid-like cells derived from the ground-state embryonic stem cells in vitro

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<正>Embryonic stem cells(ESCs)are pluripotent and can self-assemble to form cell clusters or embryoid bodies(EBs),which can then differentiate into all cell types of the three germ layers,as among which one is the primordial germ cell(PGCs)(Daley,200
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