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纤维性发育异常占所有骨新生物的2.5％,占所有良性骨瘤的7％。尚难肯定这种病变是否为发育异常,抑为外伤后的修复异常。Changus(1957)谓此病为成纤维细胞及成骨细胞对一些不明刺激的过度反应。Lichtenstein(1942)认为系成骨间质的活性改变,使骨髓腔内原始纤维组织增生,从内侵蚀骨的外层质。多年以来,此病未与原发性甲状旁腺亢进相区别,在病理学上及X线片上,将这两种骨病变描述为囊性纤维性骨炎。但早已证实,纤维性发育异常与原发性甲状旁腺功能亢进并无联系。
Fibrotic dysplasia accounts for 2.5% of all bone neoplasms and 7% of all benign osteomas. It is difficult to determine whether this disease is a developmental abnormality and is an abnormal repair after injury. Changus (1957) stated that this disease is an over-reaction of fibroblasts and osteoblasts to some unknown stimuli. Lichtenstein (1942) believes that the activity of the osteogenic interstitium changes, causing the proliferation of primitive fibrous tissue in the bone marrow cavity, which erodes the outer layer of the bone. For many years, this disease has not been distinguished from primary hyperparathyroidism. Pathologically and on X-rays, these two types of bone lesions have been described as cystic fibrosis. However, it has long been confirmed that fibrous dysplasia is not associated with primary hyperparathyroidism.