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【目的】探讨妊娠相关血浆蛋白 A与缺血性脑血管疾病之间的相关性。【方法】选择短暂脑缺血发作（T IA ）48例及缺血性脑卒中患者120例，卒中患者根据梗死体积分为小梗死灶组58例、中梗死灶组32例、大梗死灶组30例。分别测定各组血清妊娠相关血浆蛋白A （PA PP-A ）及颈动脉内膜中层厚度（IM T ）等进行组间比较。【结果】梗死组中血清PA PP-A及IM T明显高于T IA组（ P＜0．05），同时PA PP-A浓度与脑梗死面积呈正相关（ r ＝0．345，P ＜0．05）。【结论】PAPP-A对评估不同程度缺血性脑卒中是一个有用的生物学指标。“,”[Objective] To explore the relationship between pregnancy-associated plasma protein A (PAPP-A) and ischemic cerebral disease .[Methods] A total of 48 patients with transient ischemic attack(TIA) and 120 patients with ischemic stroke were enrolled in the study .According to infarction size ,patients with ische-mic stroke were divided into small infarction lesion group( n=58) ,middle infarction lesion group( n=32) and large infarction lesion group( n=30) .Serum PAPP-A and intima-media thickness(IMT) in each group were measured and compared .[Results] Serum PAPP-A and IMT in infarction group were obviously higher than those in TIA group( P<0 .05) .Meanwhile ,PAPP-A level was positively correlated with infarction size ( r =0 .345 ,P <0 .05) .[Conclusion] PAPP-A may be an useful biomarker of ischemic stroke in different degrees .