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再狭窄是血管创伤愈合的系统反应。冠状动脉成形术后再狭窄发生于术后1-3个月之间,其组织学特点是内膜增生,为非特异性反应。创伤愈合再狭窄的过程:1.炎症阶段,特点是间质细胞和血小板的聚集并释放有关生长因子,这些生长因子是间质细胞转移、增殖和胞外基质形成的主要刺激。2.肉芽发生阶段,主要是平滑肌细胞增殖。3.胞外基质改建期,间质细胞大量合成蛋白多糖,成为胞外基质的重要成份。
Restenosis is a systemic reaction to vascular wound healing. Restenosis after coronary angioplasty occurs between 1-3 months after surgery, and its histological features are intimal hyperplasia, which is a nonspecific response. Wound healing Restenosis: 1. The inflammatory phase characterized by the accumulation of interstitial cells and platelets and the release of growth-related factors that are the main stimuli for mesenchymal cell migration, proliferation and extracellular matrix formation. 2. Granulation stage, mainly smooth muscle cell proliferation. 3. Extracellular matrix remodeling period, a large number of interstitial synthesis of proteoglycan, an important component of the extracellular matrix.