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目的研究老年人肝功能异常与代谢综合征的关系。方法对2013年参加健康体检的21 928例65岁以上老年人的体检资料进行分析。分别测量身高、体重、血压,检测血脂、血糖等生化指标。血清丙氨酸转氨酶>50 U/L视为肝功能异常。结果肝功能异常检出率为2.77%;高血压、高血糖、高甘油三酯、超重或肥胖和代谢综合征的患病率分别59.57%、23.70%、30.77%、39.57%和20.20%,除高血压在肝功能正常组与异常组差别无统计学意义外,其他肝功能异常组各指标患病率均高于肝功能正常组(P≤0.01);调整年龄和性别变量后的多因素回归分析提示,肝功能异常组患代谢综合征的危险性是肝功能正常组的1.948倍,95%CI为1.633~2.324。结论高血糖、高甘油三酯、超重或肥胖等代谢综合征的主要构成组分与肝功能异常相关。
Objective To study the relationship between abnormal liver function and metabolic syndrome in the elderly. Methods The physical examination data of 21 928 elderly people over the age of 65 participating in the physical examination in 2013 were analyzed. Respectively measured height, weight, blood pressure, blood lipids, blood glucose and other biochemical indicators. Serum alanine aminotransferase> 50 U / L as liver dysfunction. Results The prevalence of abnormal liver function was 2.77%. The prevalence rates of hypertension, hyperglycemia, hypertriglyceridemia, overweight or obesity and metabolic syndrome were 59.57%, 23.70%, 30.77%, 39.57% and 20.20%, respectively Hypertension had no significant difference between normal group and abnormal group, and the prevalences of other indexes of liver dysfunction group were higher than those of normal liver function group (P≤0.01). Multivariate regression analysis after adjustment for age and sex variables The analysis suggests that the risk of metabolic syndrome in abnormal liver function group is 1.948 times of normal liver function group, 95% CI is 1.633 ~ 2.324. Conclusion The main components of metabolic syndrome such as hyperglycemia, hypertriglyceridemia, overweight or obesity are related to abnormal liver function.