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目的:探讨炎症对心房颤动(房颤)导管消融复发的影响。方法:前瞻性入选第1次行环肺静脉消融的阵发性房颤患者144例,测定血清高敏C反应蛋白(CRP),根据CRP水平通过4分位法将病例分为4组,复发定义为术后3个月后发生快速性房性心律失常。结果:平均随访91～374(199±80)d,40例(27.8%)复发。复发组CRP为(3.8±5.8)mg/L,未复发组CRP为(4.2±4.7)mg/L,2组间差异无统计学意义(P>0.05)。从CRP水平最低4分位组到CRP水平最高4分位组,复发率分别为33.3%,30.6%,25.0%,22.2%,差异无统计学意义(P>0.05)。结论:炎症标记物CRP对房颤导管消融的复发无预测价值。
Objective: To investigate the effect of inflammation on the recurrence of atrial fibrillation (AF) catheter ablation. Methods: A total of 144 patients with paroxysmal atrial fibrillation who underwent circumferential pulmonary vein ablation were prospectively enrolled. Serum high-sensitivity C-reactive protein (CRP) was measured in 144 patients. The patients were divided into 4 groups according to CRP level. The recurrence was defined as 3 months after the rapid onset of atrial arrhythmia. Results: The average follow-up ranged from 91 to 374 (199 ± 80) d, and 40 (27.8%) patients relapsed. CRP was (3.8 ± 5.8) mg / L in the recurrent group and (4.2 ± 4.7) mg / L in the non-recurrent group, with no significant difference between the two groups (P> 0.05). The recurrence rates were 33.3%, 30.6%, 25.0% and 22.2% respectively, with no significant difference (P> 0.05), from the lowest 4-place CRP level to the highest 4-place CRP level. Conclusion: There is no predictive value of CRP on the recurrence of atrial fibrillation catheter ablation.