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受体学说首先于1878年由Langley所提出,过去只是人们试图在分子水平上解释药物作用机制的一种假说,现在受体的存在已得到充分的证实,有些并可分离提纯,故已成为公认的药效学基本理论。它不仅阐明生命现象本质(包括生理过程和疾病病因方面),而且在解释药物作用机制、指导临床合理用药,以及发展新药方面都显示了极为重要的理论和实际意义,
Reciprocal theory was first proposed by Langley in 1878. In the past, it was only a hypothesis that people tried to explain the mechanism of drug action at the molecular level. Now that the receptor’s existence has been fully confirmed and some can be isolated and purified, it has become a recognized Basic theory of pharmacodynamics. It not only elucidates the essence of life phenomena (including physiological process and disease etiology), but also shows extremely important theoretical and practical significance in explaining the mechanism of drug action, guiding clinical rational drug use and developing new drugs.