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目的 :探讨补肺片治疗激素依赖型哮喘撤减激素的成功率。方法 :将 38例激素依赖型哮喘患者随机分为两组 ,治疗组 2 0例服补肺片治疗 ,对照组 18例服酮替芬片治疗 ,每年总疗程 6个月 ,连治 3年。观察两组疗效及用药前后动脉血气分析、体液免疫和肺通气功能的变化。结果 :治疗组总有效率 95 0 % ,完全撤除激素 15 % ;对照组总有效率 72 2 2 % ,完全撤除激素为 0。治疗组疗效明显优于对照组 (P <0 0 1) ,治疗后治疗组动脉血气分析PaO2 较治疗前上升 (P <0 0 0 1) ,PaCO2 较治疗前下降 (P <0 0 0 1) ;治疗后治疗组体液免疫功能水平较对照组提高 ,IgA和C3、IgM、IgG与对照组治疗前后差值比较分别为P <0 0 5～P <0 0 0 1;治疗后治疗组肺通气功能改善明显优于对照组 ,Vc、FEV1 %P <0 0 0 1,FVCP <0 0 5。结论 :补肺片替代激素治疗依赖型哮喘撤除激素有较好的临床疗效
Objective: To investigate the success rate of Bufei Tablet in hormone-dependent asthma withdrawal hormone. Methods: Thirty-eight patients with hormone-dependent asthma were randomly divided into two groups: 20 in the treatment group and 20 in the control group, and 18 in the control group. The total duration of treatment was 6 months, with a treatment of 3 years. The curative effect of the two groups were observed before and after treatment arterial blood gas analysis, humoral immunity and pulmonary ventilation function changes. Results: The total effective rate was 95 0% in the treatment group and 15% in the complete withdrawal hormone group. The total effective rate in the control group was 72 22%, and the total hormone withdrawal was 0. The curative effect of the treatment group was obviously better than that of the control group (P <0.01). After treatment, PaO2 in arterial blood gas analysis increased (P <0.01), PaCO2 decreased (P <0.01) ; After treatment, the level of humoral immune function in the treatment group was higher than that in the control group. The differences of IgA, C3, IgM, IgG and the control group before and after treatment were P <0 05 ~ P 0 01 respectively. After treatment, the lung ventilation Function improvement was significantly better than the control group, Vc, FEV1% P <0 0 0 1, FVCP <0 0 5. Conclusion: Bufei tablets alternative hormone therapy-dependent asthma withdrawal hormone has a better clinical efficacy