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1990年7月至1992年4月,56例鼻咽癌随机分为常规放疗组(对照组)和超分割放疗组。对照组放射每日1次,1.8～1.9Gy/次,每周5次。总量68.4～70.3Gy/37～38次/7.2～7.4周。超分割组1.05～1.1Gy/次,每日2次,间隔6小时,总量75.6～77Gy/70～72次/7～7.2周。超分割组的急性粘膜反应重于对照组。放射结束时临床检查鼻咽部肿瘤退缩率两组基本相似。3年生存率和无瘤生存率,对照组75.8％和42.3％。超分割组70.3％和63.3％,P>0.05。3年局部肿瘤控制率,对照组64.6％,超分割组86.7％,P<0.05。
From July 1990 to April 1992, 56 cases of nasopharyngeal carcinoma were randomly divided into conventional radiotherapy group (control group) and hyperfractionation radiotherapy group. Control group radiation once a day, 1.8 ~ 1.9Gy / times, 5 times a week. The total amount was 68.4 to 70.3 Gy/37 to 38 times/7.2 to 7.4 weeks. Hyperfractionation group 1.05 ~ 1.1Gy / time, 2 times a day, interval 6 hours, the total 75.6 ~ 77Gy / 70 ~ 72 times / 7 ~ 7.2 weeks. Acute mucosal responses in the hyperfractionated group were greater than in the control group. The clinical examination of the nasopharyngeal tumor regression rate at the end of radiation was similar in both groups. The 3-year survival rate and disease-free survival rate were 75.8% and 42.3% in the control group. Hyperfractionation group 70.3% and 63.3%, P> 0.05. 3 years local tumor control rate, control group 64.6%, hyperfractionated group 86.7%, P <0.05.