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目的:探讨中西药合用对帕金森病大鼠神经细胞凋亡的影响,并研究白藜芦醇对神经的保护效果。方法:选取90只健康SD大鼠,将其随机分为3组,即模型组、中西药治疗组、正常对照组。每组有30只健康SD大鼠。结果:模型组神经细胞凋亡数量多于正常对照组,中西药治疗组少于模型组。同时三组在电镜下观察,其神经细胞变化存在着明显的差异。结论:中西药合用能够诱导神经细胞凋亡,同时中西药可减轻西药所带来的副作用。
Objective: To investigate the effect of the combination of Chinese and western medicine on neuronal apoptosis in rats with Parkinson’s disease and to study the neuroprotective effect of resveratrol. Methods: Ninety healthy SD rats were selected and randomly divided into three groups: model group, Chinese and Western medicine treatment group and normal control group. Each group has 30 healthy SD rats. Results: The number of apoptotic nerve cells in the model group was more than that in the normal control group, but less in the TCM-WM group than in the model group. At the same time, the three groups observed under the electron microscope, there are obvious differences in the changes of nerve cells. Conclusion: The combination of Chinese and western medicine can induce apoptosis of nerve cells, while Chinese and Western medicine can reduce the side effects caused by western medicine.