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目的:通过观察品行障碍(conduct disorder,CD)青少年反馈相关负波(Feedback-related negativity,FRN)波幅与潜伏期的变化,进一步探讨其反馈评价过程的特点。方法:对21名符合DSM-IV品行障碍诊断标准的13~17岁青少年和21名正常被试完成简单赌博任务时进行ERP检测。采用FRN的波幅和潜伏期作为指标,比较CD组与正常对照组青少年评价反馈结果过程的特点。结果:1CD组与对照组相比,FRN波幅差异具有统计学意义(P<0.05),CD组FRN波幅明显减小。2CD组与对照组相比,FRN潜伏期两组间比较差异无统计学意义(P>0.05)。结论:与正常组相比,品行障碍青少年的FRN存在异常,这可能在品行障碍的发病机制与症状表现中起着重要作用。FRN波幅可能是品行障碍的属性指标。
OBJECTIVE: To explore the characteristics of the feedback evaluation process by observing the amplitude and latency of feedback-related negativity (FRN) in adulthood disorder (CD). Methods: Twenty-one adolescents aged 13 to 17 and 21 normal subjects who met the DSM-IV criteria for conduct of conduct disorder were enrolled in the ERP test for simple gambling tasks. The amplitude and latency of FRN were used as indexes to compare the characteristics of the evaluation feedback process between adolescents in CD group and normal control group. Results: Compared with the control group, the amplitude of FRN in 1CD group was significantly different (P <0.05), and the amplitude of FRN in CD group was significantly decreased. There was no significant difference between 2CD group and control group in FRN latency (P> 0.05). CONCLUSIONS: Compared with the normal group, there are abnormal FRN in adolescents with sexual dysfunction, which may play an important role in the pathogenesis and symptom manifestation of dyslexia. The volatility of the FRN may be an indicator of conduct impairment.