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肿瘤坏死因子相关凋亡诱导配体(TRAIL)可激活胱天蛋白酶(caspase)家族蛋白系列级联反应,最终诱导细胞凋亡.TRAIL选择性地诱导肿瘤细胞凋亡而不损伤正常细胞,使其成为治疗癌症的潜在药物靶点.目前已知,细胞型FADD样白介素-1-β转换酶抑制蛋白(c-FLIP)和凋亡抑制蛋白(IAPs)是肿瘤细胞对TRAIL耐受的主要原因.胱天蛋白酶原-8(procaspase-8)是TRAIL凋亡信号途径中的凋亡起始蛋白.然而近年发现,在某些肿瘤细胞中procaspase-8功能失调常会阻碍凋亡信号传导,使肿瘤细胞对TRAIL诱导的凋亡产生耐受.本文就其机制进行概述.
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) activates a caspase family of cascade cascades and ultimately induces apoptosis. TRAIL selectively induces tumor cell apoptosis without damaging normal cells Become a potential drug targets for the treatment of cancer.It is known that cell-type FADD-like interleukin-1-β converting enzyme inhibitor protein (c-FLIP) and apoptosis inhibitory protein (IAPs) are the main causes of tumor cells to TRAIL tolerance. Procaspase-8 is the apoptosis initiation protein in TRAIL apoptosis signaling pathway, however, it has been found in recent years that the dysfunction of procaspase-8 in some tumor cells often impedes the signal transduction of apoptosis, Resistant to TRAIL-induced apoptosis This paper presents an overview of its mechanism.