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大鼠、金地鼠及家兔实验证实,炔诺酮肟(NETO)抗着床作用较其母体化合物炔诺酮明显增强,临床实验证实醋炔诺酮肟作为探亲避孕效果达99.7％,而无明显毒性,药代动力学研究表明,该化合物在体内迅速转变为NETO,因此预测NETO可望发展成为事后避孕药。为促进NETO的临床试用,本文报道了NETO对大鼠的急性毒性。 实验用Wistar大鼠,体重150～300g,??兼用,随机分为四组,分别一次给予赋形剂,NETO0.13,0.63或1.25mg/kg ig。动物经乌拉坦麻醉,其中一部分接XDH—3型心电图机,以50mm/s低速观察并记录
Experiments in rats, hamsters and rabbits confirmed that the anti-implantation effect of norethindrone oxime (NETO) was significantly enhanced compared with that of its parent compound, norethindrone. Clinical trials confirmed that norethindrone acetonide oxime was 99.7% as a contraceptive for visiting relatives Clearly toxic, pharmacokinetic studies have shown that the compound quickly converted to NETO in vivo, it is predicted NETO is expected to develop into an after-treatment contraceptives. To promote the clinical trial of NETO, this paper reports the acute toxicity of NETO in rats. Experimental Wistar rats, weighing 150-300 g, were used and randomly divided into four groups and given vehicle, NETO0.13, 0.63, or 1.25 mg / kg ig respectively. The animals were anesthetized with urethane, and some of them were taken by XDH-3 electrocardiograph and observed and recorded at a low speed of 50 mm / s