TR3出核诱导细胞凋亡发生在一些药物诱导细胞系凋亡的过程中,但是否在肝癌细胞系中发生尚未见报道。我们的实验证明化疗药VP-16可以诱导7721细胞凋亡,并伴随着TR3表达量的增加。在凋亡过程中TR3从细胞核内迁移出来进入细胞质中,定位于线粒体上,说明这条信号通路在肝癌细胞中也有发生。 TR3 nuclear export-induced apoptosis occurs in some drug-induced apoptosis of cell lines, but whether it has been reported in hepatoma cell lines has not been reported yet. Our experiments show that the chemotherapeutic drug VP-16 can induce apoptosis of 7721 cells accompanied by the increase of TR3 expression. During apoptosis, TR3 migrated from the nucleus into the cytoplasm and located in the mitochondria, indicating that this signaling pathway also occurs in hepatoma cells.