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人离体血淋巴细胞在G_0、G_1、S和G_2期分别给予41℃1h加热、50 mGy小剂量照射或50 mGy和41℃1h加热联合作用,培养至48 h再给1.5GyX射线照射。结果表明三种预先处理的染色单体畸变率均明显低于单纯1.5Gy组,说明加热和小剂量X射线一样,可诱导细胞对电离辐射的抗性。但50 mGy和41℃ 1h加热联合作用的适应性反应未见累加作用,因此认为低剂量辐射和加热所诱导的适应性反应的机制可能是一致的,即通过热休克蛋白而产生保护作用。
Human blood lymphocytes were exposed to G0, G_1, S, and G2 phases at 41°C for 1 h, 50 mGy at low doses, or 50 mGy at 41°C for 1 h, and cultured for 48 h followed by 1.5 Gy X-rays. The results showed that the three pre-treated chromatid aberration rates were significantly lower than the 1.5Gy group alone, indicating that heating and low-dose X-rays can induce resistance to ionizing radiation. However, no adaptive effect was observed in the adaptive response of the combination of 50 mGy and 1 h heating at 41 °C. Therefore, the mechanism of adaptive response induced by low-dose irradiation and heating may be consistent, that is, protective effects are produced by heat shock proteins.