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[目的]探讨危急重症患者应用奥美拉唑预防应激性溃疡发生的临床疗效。[方法]选择88例危重患者,随机分为两组,治疗组采用奥美拉唑治疗,对照组采用西咪替丁治疗,比较两组SU的发生情况和病死率。[结果]治疗组46例,治疗结束后SU发生7例,发生率为15.22%;对照组42例,发生SU的14例,发生率33.33%,组间资料采用卡方检验,χ2=3.9657,P=0.0464﹤0.05,两组资料比较差异有统计学意义。治疗组死亡5例,病死率10.87%;对照组死亡11例,病死率为26.19%。两组病死率比较组间资料采用fisher检验,P=0.0405﹤0.05。两组资料比较差异有统计学意义。[结论]针对危重患者预防应激性溃疡的发生,采用奥美拉唑的治疗效果优于应用西咪替丁的治疗。
[Objective] To investigate the clinical efficacy of omeprazole in the prevention of stress ulcer in critically ill patients. [Method] Eighty-eight critically ill patients were selected and randomly divided into two groups. The treatment group was treated with omeprazole. The control group was treated with cimetidine. The incidence and mortality of SU in both groups were compared. [Results] In the treatment group, 46 cases were treated with SU and 7 cases were treated with SU. The incidence rate was 15.22%. In control group, 42 cases were SU and 14 cases were caused by the incidence rate of 33.33%. Chi-square test was used for the data of group χ2 = 3.9657, P = 0.0464 <0.05, the difference between the two groups was statistically significant. In the treatment group, 5 cases died and the case fatality rate was 10.87%. In the control group, 11 cases died and the case fatality rate was 26.19%. Data between two groups were compared using Fisher’s test, P = 0.0405 <0.05. There was significant difference between the two groups of data. [Conclusion] For the prevention of stress ulcer in critically ill patients, the treatment with omeprazole is superior to the treatment with cimetidine.