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本实验将43个癌高发家族中67例高SCE率的易患个体随机分为两组,服维生素A组47例,对照组20例,其结果,服维生素A3个月后SCE率明显下降,与对照组比较差异非常显著,P值<0.01。有报道认为SCE的形成与基因突变有密切的关系,SCE的长期升高可作为癌变的警告信号。维生素A类药物对多种化学致癌剂诱发的肿瘤均有预防和治疗作用,血清中维生素A水平低下,癌症的发生率增高。本实验用维生素A对癌家族高危人群SCE率的影响,结果是显著的,这种小剂量维生素A使细胞SCE率下降的原理可能与维生素A类药物对细胞基因表达的调节作用有关。
In this experiment, 67 high-SCE predisposing individuals in 43 high-risk families were randomly divided into two groups: 47 patients in the vitamin A group and 20 in the control group. As a result, the SCE rate decreased significantly after taking vitamin A for 3 months. The difference from the control group was very significant, P value < 0.01. It has been reported that the formation of SCE has a close relationship with gene mutations, and the long-term increase of SCE may serve as a warning sign of canceration. Vitamin A drugs have a preventive and therapeutic effect on tumors induced by a variety of chemical carcinogens. Serum vitamin A levels are low, and the incidence of cancer increases. In this experiment, the effect of vitamin A on the SCE rate of cancer family high-risk population was significant. The principle that this low-dose vitamin A may decrease the SCE rate of cells may be related to the regulation effect of vitamin A drugs on cell gene expression.