Angew.Chem.Int.Ed.2015,54,4023~4027α-取代的酯类化合物是一类非常重要的有机合成中间体,而酯的α-烷基化反应是合成这类化合物的重要途径.传统的烷基化方法是采用酯与强碱在极低温度下形成的烯醇中间体对卤代烃进行亲核进攻,生成α-取代的酯.然而,这种方法使用的烷基化试剂的毒性较大,反应条件苛刻,底物适用性窄,并且会产生污染环境的无机盐类副产物.近年来,以一级醇作为烷基化试剂,利用“借氢策略”进行的金属催化的烷基化反应,为α-取代酯的合成提供了一条 Angew.Chem.Int.Ed.2015,54,4023 ~ 4027 α-Substituted ester compounds are a very important class of organic synthesis intermediates. Ester α-alkylation is an important way to synthesize these compounds. The traditional alkylation process is the nucleophilic attack of halohydrocarbons using enol intermediates formed by the reaction of esters with strong bases at very low temperatures to form α-substituted esters. However, the alkylating reagents used in this method The toxicity is high, the reaction conditions are harsh, the substrate is narrow applicability, and will produce inorganic salts that pollute the environment byproducts .In recent years, with the first grade alcohol as alkylating reagent, the use of “hydrogen strategy” Metal-catalyzed alkylation provides one for the synthesis of α-substituted esters