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目的 :探讨西比灵对蛛网膜下腔出血 (SAH)后观察两组治疗前后与对照组血浆 ,脑脊液 (CSF)内皮素 (ET)、降钙基因相关肽(CGRP)水平变化。方法 :将 62例SAH患者随机分为西比灵组及非西比灵组测定治疗前后血和脑脊液ET、CGRP。结果 :西比灵及非西比灵组治疗前ET水平较对照组明显升高 ,CGRP明显降低 ;西比灵组治疗后ET水平较治疗前明显降低 ,CGRP明显升高 ,非西比灵组治疗前后ET、CGRP水平无显著变化。结论 :西比灵治疗后通过抑制ET产生和释放 ,增加CGRP合成有关。可能有防治SAH后脑血管痉挛作用
Objective: To investigate the changes of endothelin (ET) and calcitonin gene related peptide (CGRP) levels in plasma and cerebrospinal fluid (CSF) of the two groups before and after subarachnoid hemorrhage (SAH). Methods: Sixty-two patients with SAH were randomly divided into xibinger group and non-xibeiling group for determination of blood and cerebrospinal fluid ET and CGRP before and after treatment. Results: Compared with the control group, the levels of ET in the xibinger and the non-xibiritin groups were significantly higher than those in the control group, while the levels of CGRP in the xibinger group were significantly decreased. The levels of ET in the xibiritin group were significantly lower than those before treatment and CGRP levels were significantly increased Before and after treatment ET, CGRP levels did not change significantly. Conclusion: Xibei Ling after treatment by inhibiting the production and release of ET, increased CGRP synthesis. There may be prevention and treatment of cerebral vasospasm after SAH