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降钙素基因相关肽(CGRP)和内皮素(ET)分别是目前巳知体内最强的舒血管及缩血管活性多肽.国外学者分别对ET及CGRP作过临床观察,发现急性心肌梗死(AMI)行静脉溶栓后,冠脉再通者,血浆CGRP及ET浓度早期明显增加,后期明显降低;溶栓未通者在发病初CGRP及ET浓度较正常也呈先升后降趋势,两者之间的具体对应关系如何未见有报道.本文通过监测血浆ET/CGRP的比值,旨在探讨该比值对判断溶栓后冠状动脉再通的意义.1 资料及方法1.1 对象符合WHO诊断标准的鄂州市第一医院及同济医院的两院AMI住院病人(选择发病12小时内)46例,男29例,女17例,年龄40～73(62.3)岁,按溶栓情况分为三组:(I)再通组:静脉溶栓成功17例,
Calcitonin gene-related peptide (CGRP) and endothelin (ET) are known to be the strongest vasodilator and vasoconstrictor peptides in the body, respectively. Foreign scholars have made clinical observations on ET and CGRP respectively and found that acute myocardial infarction (AMI ) After intravenous thrombolysis, coronary recanalization, plasma CGRP and ET concentrations were significantly increased early and late significantly decreased; thrombolytic patients at the onset of early CGRP and ET concentrations were also increased first and then decreased, both The specific correspondence between how the report has not been reported.This paper by monitoring the ratio of plasma ET / CGRP aims to explore the ratio of the significance of judging the coronary recanalization after thrombolysis.1 Materials and Methods 1.1 object in line with the WHO diagnostic criteria 46 patients with 29 AMI and 17 women aged 40-73 years old (62.3 years) were divided into three groups according to the thrombolytic situation: the first hospital of Ezhou and the second hospital of Tongji Hospital, (I) recanalization group: 17 cases of successful intravenous thrombolysis,