肝纤维化是多数慢性肝病共有的病理特征,是发展到肝硬化的必经阶段,由于肝纤维化有逆转的可能,故对其治疗的研究成为热点。西医治疗肝纤维化由于其自身难以克服的不良反应而难广泛应用于临床。中医药治疗肝纤维化历史悠久,近几年来,学者们对众多中药提取物的有效成分进行了广泛而深入的抗肝纤维化研究,效果较为满意。1.粉防己碱:又名汉防己甲素,提取于粉防己根。近年研究发现其可通过提高一氧化氮合酶活性,增加一氧化氮合成、释放,抑制成纤维细胞增殖及胶原合成而抗肝纤维化。王志荣等还发现其能显著抑制诱导的肝纤维化大鼠肝组织c-fos和c- Liver fibrosis is a common pathological feature of most chronic liver diseases. It is a necessary stage for the development of liver cirrhosis. Due to the possibility of reversal of liver fibrosis, the study of its treatment has become a hot topic. Western medicine treatment of liver fibrosis is difficult to use widely in clinical practice because of its own insurmountable adverse reactions. Chinese medicine has a long history in the treatment of hepatic fibrosis. In recent years, scholars have conducted extensive and in-depth anti-hepatic fibrosis studies on the active ingredients of many Chinese herbal extracts, and the results have been relatively satisfactory. 1. Tetrandrine: Also known as Tetrandrine, it is extracted from the root of the powder. Recent studies have found that it can prevent liver fibrosis by increasing the activity of nitric oxide synthase, increasing the synthesis and release of nitric oxide, inhibiting fibroblast proliferation and collagen synthesis. Wang Zhirong et al. also found that it can significantly inhibit hepatic c-fos and c-induced liver fibrosis in rats.