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目的探讨中药Formula-3治疗BN大鼠食物过敏的效果及作用机制。方法建立卵清蛋白(OVA)大鼠食物过敏模型,通过中药Formula-3治疗后对相关指标进行检测。结果与OVA实验组相比,中药Formula-3治疗后血清中特异性Ig E水平明显降低(P<0.05),血清中组胺水平亦降低(P<0.05)。肠组织切片HE染色和甲苯胺蓝染色可见Formula-3治疗组肠组织病理变化和肥大细胞脱颗粒现象较OVA实验组有了显著的改善(P<0.05)。结论中药Formula-3可以有效治疗BN大鼠食物过敏,为治疗食物过敏性疾病提供理论依据。
Objective To investigate the effect and mechanism of Chinese traditional medicine Formula-3 on food allergy in BN rats. Methods The food allergy model of ovalbumin (OVA) rats was established. After treatment with TCM Formula-3, the related indexes were detected. Results Compared with the OVA experimental group, the serum IgE level was significantly decreased (P <0.05) and the serum histamine level was also decreased (P <0.05). The histological changes of intestinal tissue and degranulation of mast cells in Formula-3 treatment group were significantly improved compared with OVA experimental group (P <0.05) by HE staining and toluidine blue staining of intestinal tissue sections. Conclusion Chinese traditional medicine Formula-3 can effectively treat food allergy in BN rats and provide a theoretical basis for the treatment of food allergy diseases.