目的:研究何首乌对自然衰老大脑学习记忆能力的影响。方法:建立小鼠自然衰老模型,通过给小鼠长期饮用不同浓度的何首乌,来评价何首乌对自然衰老大脑学习记忆能力的影响。结果:长期饮用不同浓度何首乌后,小鼠到达Morris水迷宫平台时间显著缩短,错误次数明显降低。结论:何首乌增强自然衰老大脑的学习记忆能力。 Objective: To study the effect of fleece-flower root on the learning and memory abilities of natural aging brain. Methods: A mouse model of natural aging was established. The effects of Polygonum multiflorum Thunb. On learning and memory of natural aging brain were evaluated by long-term drinking different concentrations of Polygonum multiflorum. Results: Long-term drinking different concentrations of Polygonum multiflorum, mice reached the Morris water maze platform significantly shortened the time, the number of errors significantly reduced. Conclusion: Polygonum multiflorum enhance learning and memory ability of natural aging brain.