综合国内外大量文献,简单介绍N-乙酰基-5-甲氧基色胺(褪黑素)的化学合成的理化性质、生理活性、用途和化学合成工艺路线,并提出了一条以丙二酸二乙酯和丙烯腈为起始原料的适合工业生产的简便、经济的化学合成方法,该工艺具有原料易得、反应条件温和、质量好和收率高等特点。 Based on a large amount of domestic and foreign literatures, the chemical and physical properties, physiological activities, uses and chemical synthesis routes of N-acetyl-5-methoxytryptamine (melatonin) are briefly introduced. Ethyl acetate and acrylonitrile as starting materials for the industrial production of simple, economical chemical synthesis method, the process has the raw materials available, mild reaction conditions, good quality and high yield characteristics.