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据文献报道:化学等值的呋喃(口旦)啶(以下简称NFT)肠溶衣片不一定生物等效。美国食物药品管理局(FDA)规定NFT片剂需作体外溶出速率试验。不同的呋喃(口旦)啶原料、粒子大小、剂型、赋形剂、制备工艺以及药物相互作用等均可影响其疗效及毒副作用。国内对NFT肠溶衣片体内动力学及生物利用度
It has been reported in the literature that chemically equivalent furan (denudan) (hereinafter referred to as NFT) enteric-coated tablets are not necessarily bioequivalent. The United States Food and Drug Administration (FDA) NFT tablets require in vitro dissolution rate test. Different furosemide (oral Dan) raw materials, particle size, dosage form, excipients, preparation process and drug interactions can affect its efficacy and side effects. Domestic NFT enteric-coated tablets in vivo kinetics and bioavailability