目的 :总结皮层下动脉硬化性脑病 (SAE)临床、影像学表现及诊断要点。方法 :对临床资料完整并经CT扫描的 330例 (其中 5 4例加磁共振成像 )进行分析。结果 :进行性智能障碍是SAE的主要临床表现 ,CT显示脑内白质区多发低信号灶 ,MRI表现为长T1、长T2 异常信号灶 ,同时合并多发腔隙性脑梗死和脑萎缩。结论 :CT平扫结合临床是SAE最简便有效的诊断手段 ,MRI能更敏感地显示合并的脑内细小梗死灶。 Objective: To summarize the clinical and imaging findings and diagnosis points of subcortical arteriosclerotic encephalopathy (SAE). Methods: The clinical data were analyzed by CT scan of 330 cases (including 54 cases with magnetic resonance imaging). Results: Progressive intellectual impairment was the main clinical manifestation of SAE. CT showed multiple low signal lesions in the white matter area of ​​the brain. MRI showed long T1 and long T2 abnormal signal lesions with concurrent lacunar infarction and brain atrophy. Conclusion: CT scan combined with clinical diagnosis of SAE is the most simple and effective means of diagnosis, MRI can be more sensitive to show small intracranial infarction.